![]() It is noted in The Shulgin Index Volume 1: Psychedelic Phenethylamines and Related Compounds where the synthesis is written "from 2C-I (with trifluoroacetic anhydride) to 1-(2,5-dimethoxy-4-iodophenyl)-2-(trifluoroacetamido)ethane (with methyl chlorodifluoroacetate, KF, Cul) to 1-(2,5-dimethoxy-4-trifluoromethylphenyl)-2-(trifluoroacetamido)ethane (with KOH) to 2C-TFM." The synthesis was published by Nichols and his research team. The high binding affinity conferred by the 4-trifluoromethyl group is demonstrated by the fact that 2C-TFM is one of the only simple phenethylamines to rival the potency of psychedelic amphetamines like DOI and DOB, in both in vitro studies and human trials. ![]() 2C-TFM displaced radiolabelled ketanserin from 5-HT 2A/C receptors with a K i of 74.5 nM, as compared to a K i of 80.9 nM for the more well known 5-HT 2A agonist DOI, indicating similar binding affinity at the receptor. The mechanism that produces the hallucinogenic and entheogenic effects of 2C-TFM is most likely to result from action as a 5-HT 2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines. There have been no reported deaths or hospitalizations from 2C-TFM.Īs of October 31st, 2016, 2C-TFM is a controlled substance (Schedule III) in Canada. In the wake of Operation Web Tryp in July 2004, the issue of possession and sales of 2C-TFM and other similar chemicals will probably be resolved in the courtroom as well the fate of this rare but unique psychedelic. ![]() However, 2C-TFM, unlike many other phenethylamines, has not been widely sold by internet retailers. Legality United States ĢC-TFM is unscheduled and uncontrolled in the United States, but possession and sales of 2C-TFM could potentially be prosecuted under the Federal Analog Act because of its structural similarities to 2C-B and 2C-T-7. It is considered to be the strongest 2C variation. Very little data exists, but some reports suggest 2C-TFM produces psychedelic (hallucinogenic/entheogenic) effects that last between 5 and 7 hours. The full name of the chemical is 2-ethanamine.Ī psychedelic dosage of 2C-TFM is reported to be 3–5 mg. It has also been called 2C-CF 3, a name derived from the Para-trifluoromethyl group it contains.ĢC-TFM is a code that represents 4-tri fluoro methyl-2,5-di methoxy phenethylamine. It was first synthesized in the laboratory of David E. 2C-TFM is a psychedelic phenethylamine of the 2C family.
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